The first traces of human presence in the prefecture appear 30,000 years ago in the Aggitis cave. Organized life is found in the Neolithic settlements of the region.
In historical times the Thracian tribes worshiped Dionysus and submitted to King Philip at the end of the classical era, while the area belonged to the borders of the Roman colony of Philippi.
In the Byzantine times, the castle of Drama saw successive Byzantine and foreign rulers.
Finally, in 1383 and until 1912, the region came under the rule of the Ottomans, while it was shaken at the end of the period by the Macedonian struggle. Released on July 1, 1913.
In modern times, the development of the region was supported by tobacco and in the interwar period by the arrival of 80,000 Greek refugees from Asia Minor, Pontus and Thrace.

Editor: Fotini Anastasopoulou